Association of structural variants of the gene of apolipoprotein B with coronary heart disease and serum lipid level
Journal Article
·
· Russian Journal of Genetics
OSTI ID:70456
- Institute of Medical Genetics, Tomsk (Russian Federation)
- Institute of Cardiology, Tomsk (Russian Federation)
Xba I and EcoR I polymorphism of the apolipoprotein B (APOB) gene was studied by PCR. A significant increase in the frequency of allele X{sup +} and haplotype X{sup +}E{sup +} was demonstrated in patients with coronarographically documented coronary heart disease (CHD) over that of the general population. Association of allele E{sup {minus}} with increased levels of serum triglycerides was found. The results provide evidence about the contribution of structural variants of the APOB gene to determining CHD. 21 refs., 4 tabs.
- OSTI ID:
- 70456
- Journal Information:
- Russian Journal of Genetics, Journal Name: Russian Journal of Genetics Journal Issue: 3 Vol. 31; ISSN RJGEEQ; ISSN 1022-7954
- Country of Publication:
- United States
- Language:
- English
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