Multipoint linkage analysis using sib pairs: A interval mapping approach for dichotomous outcomes

Journal Article · Wed Mar 01 04:00:00 EST 1995 · American Journal of Human Genetics

OSTI ID:70451

Olson, J M ^[1]

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1. Roswell Park Cancer Institute, Buffalo, NY (United States)

I propose an interval mapping approach suitable for a dichotomous outcome, with emphasis on samples of affected sib pairs. The method computes a lod score for each of a set of locations in the interval between two flanking markers and takes as its estimate of trait-locus location the maximum lod score in the interval, provided it exceeds the prespecified critical value. Use of the method depends on prior knowledge of the genetic model for the disease only through available estimates of recurrence risk to relatives of affected individuals. The method gives an unbiased estimate of location, provided the recurrence risks are correctly specified and provided the marker identity-by-descent probabilities are jointly, rather than individually, estimated. I also discuss use of the method for traits determined by two loci and give an approximation that has good power for a wide range of two-locus models. 25 refs., 2 figs., 9 tabs.

• OSTI ID: 70451
• Journal Information: American Journal of Human Genetics, Journal Name: American Journal of Human Genetics Journal Issue: 3 Vol. 56; ISSN AJHGAG; ISSN 0002-9297
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
99 GENERAL AND MISCELLANEOUS
CALCULATION METHODS
GENES
GENETIC MAPPING
HUMAN CHROMOSOMES
STATISTICAL MODELS