Characterization of soman toxicity in atropine and oxime (Hi-6 and MMB-4) treated rhesus monkeys

Technical Report · Thu May 13 00:00:00 EDT 1993

OSTI ID:7043517

Olson, C T; Menton, R G; Kiser, R C; Hobson, D W

There is a need for improved therapeutic compounds, specifically oximes, for humans exposed to organophosphorus (OP) anticholinesterase agents. Although pyridine-2-aldoxime (pralidoxime chloride; 2-PAM), the standard therapeutic oxime, is effective for treating exposure to certain OPs, it is only a marginally effective treatment for intoxications produced by other OPs such as pinacolylmethylphosphonofluoridate (soman; GD). Two bispyridinium oximes, HI-6 and MMB-4, have been suggested as replacements for 2-PAM in the treatment of OP intoxications in man. A study was conducted at Battelle's Medical Research and Evaluation Facility to determine the efficacies of HI-6 and MMB-4, given with atropine, in alleviating the signs of GD intoxication in monkeys. Treatments were administered 1 min after GD injection using a demonstrated efficacious dose of 0.4 mg atropine free base per kilogram of body weight, and 100 umol/kg of either candidate oxime. Although there is not a complete understanding of mechanism(s) of action, HI-6 proved more efficacious than MMB-4 in preventing lethality and in decreasing duration of clinical signs of GD intoxication.

• Research Organization: Battelle Memorial Inst., Columbus, OH (United States)
• OSTI ID: 7043517
• Report Number(s): AD-P-008815/3/XAB; CNN: DAMD17-89-C-9050
• Country of Publication: United States
• Language: English

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