The transformation of nitriles into amides using sodium percarbonate

Journal Article · Mon Jan 01 04:00:00 EST 1990 · Synthetic Communications; (United States)

DOI:https://doi.org/10.1080/00397919008052860· OSTI ID:7037451

Kabalka, G W; Deshpande, S M; Wadgaonkar, P P; Chatla, N ^[1]

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1. Univ. of Tennessee, Knoxville (United States)

The usefulness of sodium percarbonate, an inexpensive, safe and easily handled reagent for the transformation of nitriles into amides was investigated. Aromatic nitriles lacking ortho-substituents and heteroaromatic nitriles were efficiently transformed into amides; while ortho-substituted aromatic nitriles and aliphatic nitriles gave moderate yields of the corresponding amides.

• DOE Contract Number: FG05-86ER60434
• OSTI ID: 7037451
• Journal Information: Synthetic Communications; (United States), Journal Name: Synthetic Communications; (United States) Vol. 20:10; ISSN SYNCA; ISSN 0039-7911
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
400201* -- Chemical & Physicochemical Properties
ALKALI METAL COMPOUNDS
AMIDES
CARBON COMPOUNDS
CARBONATES
CHEMICAL PREPARATION
CHEMICAL REACTION KINETICS
CHEMICAL REACTION YIELD
HYDROGEN COMPOUNDS
HYDROGEN PEROXIDE
KINETICS
NITRILES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXYGEN COMPOUNDS
PEROXIDES
REACTION KINETICS
SODIUM CARBONATES
SODIUM COMPOUNDS
SYNTHESIS
TEMPERATURE RANGE
TEMPERATURE RANGE 0273-0400 K
YIELDS