Multiple animal studies for medical chemical defense program in soldier/patient decontamination and drug development. Task 85-18. Appendix A. Protocol, amendments and deviations. Final report, June 1985-August 1988
Technical Report
·
OSTI ID:7037102
This study was conducted to evaluate the efficacy of the reversible acetylcholinesterase inhibitor, pyridostigmine bromide, as a addition to standard therapy with atropine and pralidoxime chloride (2-PAM), against the acute lethal effects of Soman, GD, using a primate model (male, Rhesus monkey). In addition, the pharmacokinetics of pyridostigmine bromide (intragastric), atropine (intramuscular), and 2-PAM (intramuscular) were individually examined in the primate model using three different dose levels for each compound. In the efficacy study, the combined prophylactic/post-challenge therapy regimen resulted in survival following an intramuscular challenge dose as high as 617 micro g/kg in contrast to an estimated, unprotected, median lethal GD dose (LD50) of 15.3 micro g/kg for the same animals.
- Research Organization:
- Battelle Memorial Inst., Columbus, OH (United States)
- OSTI ID:
- 7037102
- Report Number(s):
- AD-B-127278/0/XAB; CNN: DAMD17-83-C-3129
- Country of Publication:
- United States
- Language:
- English
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