Multiple animal studies for medical chemical defense program in soldier/patient decontamination and drug development on task order 85-13: Advanced screening system for evaluating barrier compounds for protection from organophosphate chemical surety material using a nonlethal end point, acetylcholinesterase inhibition. Final report, 1 January 1985-1 September 1988
This task was initiated at the Medical Research and Evaluation Facility to develop a protocol for advanced screening of candidate barrier compounds for protection from nerve agents using a quantifiable nonlethal end point as a measure of effectiveness. Soman (GD), thickened GD (TGD), and VX were used to generate a family of curves for erythrocyte (RBC) acetylcholinesterase (AChE) inhibition as a function these data, a single dose was selected for each agent to challenge barrier-protected and unprotected animals. Blood samples were drawn at three times after exposure from each group of agent-challenged animals to validate the model by comparing AChE depression and rate of inhibition in unprotected and barrier-protected animals. Screen, organophosphate, chemical surety materiel, TGD, GD, VX, acetylcholinesterase inhibition, barrier compounds, nonlethal end point, PEG 540, rabbits.
- Research Organization:
- Battelle Memorial Inst., Columbus, OH (United States)
- OSTI ID:
- 7036983
- Report Number(s):
- AD-B-127740/9/XAB; CNN: DAMD17-83-C-3129
- Country of Publication:
- United States
- Language:
- English
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