Kinetic analysis of zinc uptake and serosal transfer by vascularly perfused rat intestine

Journal Article · Mon Jun 01 00:00:00 EDT 1987 · Am. J. Physiol.; (United States)

OSTI ID:7036980

Hoadley, J E; Leinart, A S; Cousins, R J

Transport kinetics were examined for uptake of /sup 65/Zn from the lumen and for transport of mucosal /sup 65/Zn subsequent to uptake in the isolated, vascularly perfused intestines of rats fed either a zinc-deficient or zinc-adequate diet. Zinc depletion influenced the intestinal transport of zinc by 1) stimulating a saturable uptake mechanisms, 2) reducing secretion of mucosal /sup 65/Zn into the lumen, and 3) increasing the rate of /sup 65/Zn turnover in a rapidly absorbed mucosal zinc compartment. Uptake of /sup 65/Zn involved both saturable and nonsaturable processes. The saturable process was stimulated by zinc depletion with the apparent maximal transport rate for the saturable mechanism increasing from 60 to 180 nmol Zn x g/sup -1/ x 30 min/sup -1/. Most of the /sup 65/Zn taken up was not involved in the short-term secretion or absorption, and mucosal /sup 65/Zn retention was independent of dietary zinc status. Absorption of mucosal /sup 65/Zn was nonsaturable, involved a rapid exchanging zinc compartment, and was stimulated by zinc depletion. The half-life for /sup 65/Zn in this mucosal zinc compartment was approx. 24 min in the zinc-adequate group and 13 min in the zinc-depleted group.

• Research Organization: Univ. of Florida, Gainesville (USA)
• OSTI ID: 7036980
• Journal Information: Am. J. Physiol.; (United States), Journal Name: Am. J. Physiol.; (United States) Vol. 252:6; ISSN AJPHA
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION
ALDEHYDES
ANIMAL TISSUES
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