Neurologic syndrome in 25 workers from an aluminum smelting plant

Journal Article · Wed Jul 01 04:00:00 EDT 1992 · Archives of Internal Medicine; (United States)

DOI:https://doi.org/10.1001/archinte.152.7.1443· OSTI ID:7036320

White, D M; Longstreth, Jr, W T; Rosenstock, L; Claypoole, K H; Brodkin, C A; Townes, B D ^[1]

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1. Department of Rehabilitation Medicine, University of Washington Medical Center, Seattle (United States)

This article expands on an earlier series of three patients with a neurologic syndrome, who had all worked in an aluminum smelting plant. Twenty-five symptomatic workers from the same plant were referred for a standardized evaluation, including completion of a health questionnaire, neurologic examination, and neuropsychologic evaluation. An exposure index was calculated for each worker based on level and duration of exposure in the potroom, where exposures were the greatest. This index was correlated with symptoms, signs, and neuropsychologic test scores. Twenty-two (88%) of the patients reported frequent loss of balance, and 21 (84%) reported memory loss. Neurologic examination revealed signs of incoordination in 21 (84%) of the patients. Neuropsychologic test results showed preservation in certain spheres of functioning, such as verbal IQ, with substantial impairment in others, particularly memory functioning. On memory tests, 70% to 75% showed mild or greater impairment. The majority (17 of 19 tested, or 89%) showed depression on the Minnesota Multiphasic Personality Inventory. The exposure index was significantly correlated with signs and symptoms of incoordination. This study and others in humans and animals support the existence of a syndrome characterized by incoordination, poor memory, impairment in abstract reasoning, and depression. Aluminum exposure in the potroom seems the most likely cause.

• OSTI ID: 7036320
• Journal Information: Archives of Internal Medicine; (United States), Journal Name: Archives of Internal Medicine; (United States) Vol. 152:7; ISSN AIMDA; ISSN 0003-9926
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALUMINIUM
ANIMALS
DISEASES
ELEMENTS
EPIDEMIOLOGY
MAMMALS
MAN
METALLURGY
METALS
NERVOUS SYSTEM DISEASES
OCCUPATIONAL DISEASES
OCCUPATIONAL EXPOSURE
PERSONNEL
PRIMATES
SYMPTOMS
TOXICITY
VERTEBRATES