Assignment of the human FAU gene to a subregion of chromosome 11q13

Journal Article · Sun Aug 01 04:00:00 EDT 1993 · Genomics; (United States)

DOI:https://doi.org/10.1006/geno.1993.1337· OSTI ID:7035543

Kas, K; Michiels, L; Merregaret, J ^[1]; Schoenmakers, E; Van De Ven, W ^[2]; Weber, G; Nordenskjoeld, M; Larsson, C ^[3]

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1. Univ. of Antwerp, Wilrijk (Belgium)
2. Center for Human Henetics, Leuven (Belgium)
3. Karolinska Hospital, Stockholm (Sweden)

The FAU gene is the cellular homologue of the fox sequence in the Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV). FAU (for FBR-MuSV associated ubiquitously expressed gene) encodes the ribosomal protein S30 fused to a ubiquitin-like protein. A cosmid clone containing the human FAU gene was used for fluorescence in situ hybridization to metaphase chromosomes. The obtained localization to 11q13 was confirmed by hybridization against a panel of somatic cell hybrids containing different parts of chromosome 11 on a hamster background. FAU was then further mapped, both on a panel of radiation-reduced somatic cell hybrids designed to carry different parts of the 11q13 region and by pulsed-field gel electrophoresis. This fine mapping assigned FAU close to the skeletal muscle glycogen phosphorylase gene (PYGM), in a region that contains several oncogenes as well as the putative tumor suppressor genes MEN1 and ST3. 33 refs., 3 figs.

• OSTI ID: 7035543
• Journal Information: Genomics; (United States), Journal Name: Genomics; (United States) Vol. 17:2; ISSN GNMCEP; ISSN 0888-7543
• Country of Publication: United States
• Language: English

Related Subjects

550400* -- Genetics
59 BASIC BIOLOGICAL SCIENCES
CHROMOSOMES
GENES
GENETIC MAPPING
HUMAN CHROMOSOMES
MAPPING
MICROORGANISMS
ONCOGENIC VIRUSES
PARASITES
VIRUSES