Liquid chromatography/mass spectrometry

Journal Article · Mon Dec 01 00:00:00 EST 1986 · Anal. Chem.; (United States)

DOI:https://doi.org/10.1021/ac00127a001· OSTI ID:7033789

Covey, T R; Lee, E D; Bruins, A P; Henion, J D

The combination of high-performance liquid chromatography (HPLC) and mass spectrometry (MS) offers the analytical chemist one of the most powerful analytical techniques of modern times. Both techniques have matured to the point that they represent two of the most important tools available for the characterization of organic compounds. Unfortunately, coupling these techniques (LC/MS) has been a more challenging task than it was for gas chromatography/mass spectrometry (GC/MS). The potential benefits derived from on-line coupling of LC to MS have been known for about 12 years. The problems associated with interfacing these two techniques in a practical way are considerable, but recently there has been significant progress toward this end. An excellent review covering the status of this subject through 1978 appeared in this journal, and this article will attempt to cover the state of the art through early 1986. As with any rapidly developing area, the details of all aspects of LC/MS cannot be covered in a short overview. The reader may refer to the references and recent reviews more information on other aspects of this subject.

• Research Organization: Cornell Univ., Ithaca, NY
• OSTI ID: 7033789
• Journal Information: Anal. Chem.; (United States), Vol. 58:14
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC
ORGANIC
PHYSICAL AND ANALYTICAL CHEMISTRY
LIQUID COLUMN CHROMATOGRAPHY
REVIEWS
USES
MASS SPECTROSCOPY
ELUTRIATION
QUANTITATIVE CHEMICAL ANALYSIS
SAMPLE PREPARATION
CHEMICAL ANALYSIS
CHROMATOGRAPHY
DOCUMENT TYPES
SEPARATION PROCESSES
SPECTROSCOPY
400102* - Chemical & Spectral Procedures