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In vivo spiperone binding is altered by dopaminergic pathway stimulation

Conference · · J. Nucl. Med.; (United States)
OSTI ID:7033497
; ;
Measurement of dopamine receptors in humans with (C-11) methylspiperone and positron emission tomography holds great potential for increasing the understanding of brain function. In order to determine whether endogenous dopamine can compete with (H-3)spiperone ((H-3)SP) binding in vivo in the striatum, the authors stimulated the nigrostriatal pathway unilaterally and measured left/right striatal accumulation of (H-3)SP in rats. Bipolar electrodes were implanted in rat substantia nigra pars compacta one week prior to experiments. These studies demonstrate that altering the firing rate and dopamine release in the nigrostriatal pathway can produce a change in the in vivo accumulation of (H-3)SP in striatum. These results indicate that in vivo binding studies are measuring a dynamic process-perhaps agonist-mediated receptor internalization-not a static number of receptor sites.
Research Organization:
UCLA School of Medicine, Los Angeles, CA
OSTI ID:
7033497
Report Number(s):
CONF-850611-
Conference Information:
Journal Name: J. Nucl. Med.; (United States) Journal Volume: 26:5
Country of Publication:
United States
Language:
English

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550201 -- Biochemistry-- Tracer Techniques
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59 BASIC BIOLOGICAL SCIENCES
AMINES
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOCHEMISTRY
BODY
BRAIN
CARDIOTONICS
CARDIOVASCULAR AGENTS
CENTRAL NERVOUS SYSTEM
CEREBRUM
CHEMISTRY
COMPUTERIZED TOMOGRAPHY
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DISTRIBUTION
DOPAMINE
DRUGS
DYNAMIC FUNCTION STUDIES
EMISSION COMPUTED TOMOGRAPHY
HYDROXY COMPOUNDS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MEMBRANE PROTEINS
METABOLISM
NERVOUS SYSTEM
NEUROREGULATORS
ORGANIC COMPOUNDS
ORGANS
PHENOLS
POLYPHENOLS
POSITRON COMPUTED TOMOGRAPHY
PROTEINS
RADIOISOTOPE SCANNING
RADIORECEPTOR ASSAY
RATS
RECEPTORS
RODENTS
SAMPLE PREPARATION
SCINTISCANNING
SYMPATHOMIMETICS
TISSUE DISTRIBUTION
TOMOGRAPHY
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES