Microdosimetric calculations of boron-drug compound factors for boron neutron capture therapy

Conference · Tue Dec 31 23:00:00 EST 1991 · Transactions of the American Nuclear Society; (United States)

OSTI ID:7033208

Wheeler, F J ^[1]

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1. Idaho National Engineering Lab., Idaho Falls (United States)

The relative biological effect (RBE) is not a useful term to describe {sup 10}B capture events because dose is not a greatly useful term for boron neutron capture therapy (BNCT), and each drug compound exhibits unique pharmacokinetics, resulting in differences in {sup 10}B spatial distributions and tremendous variation in biological effect. These considerations have led to the suggestion that a quantity called the compound factor' (CF) be defined. The CF can replace RBE for BNCT terminology and avoid some misinterpretations caused by quoting RBE values. A study was performed to estimate CFs in normal brain and brain-tumor tissues for borocaptate sodium (Na{sub 2}B{sub 12}H{sub 11}SH (BSH)) and para-boronophenylalanine (p-BPA). A Monte Carlo computer model of the capillaries was used to determine charged-particle energy deposition patterns following {sup 10}B capture events in various regions within and around the endothelial cell. A spherical model of tumor cells was also used to determine energy transport in the tumor. The tumor cells were assumed to be 10 {mu}m in diameter with 5-{mu}m-diam nuclei, and extracellular space occupied 15% of the volume. From these Monte Carlo results, transmission factors were obtained for energy deposition to the nucleus due to {sup 10}B capture events in any region within and external to the cells.

• OSTI ID: 7033208
• Report Number(s): CONF-920606--
• Journal Information: Transactions of the American Nuclear Society; (United States), Journal Name: Transactions of the American Nuclear Society; (United States) Vol. 65; ISSN TANSA; ISSN 0003-018X
• Country of Publication: United States
• Language: English

Related Subjects

550604* -- Medicine-- Unsealed Radionuclides in Therapy-- (1980-)
560101 -- Biomedical Sciences
Applied Studies-- Radiation Effects-- Dosimetry & Monitoring-- (1992-)
61 RADIATION PROTECTION AND DOSIMETRY
62 RADIOLOGY AND NUCLEAR MEDICINE
BODY
BORON 10
BORON ISOTOPES
BRAIN
CENTRAL NERVOUS SYSTEM
COMPUTERIZED SIMULATION
DISEASES
DISTRIBUTION
DOSIMETRY
DRUGS
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MEDICINE
MICRODOSIMETRY
MONTE CARLO METHOD
NEOPLASMS
NERVOUS SYSTEM
NEUTRON CAPTURE THERAPY
NEUTRON THERAPY
NUCLEAR MEDICINE
NUCLEI
ODD-ODD NUCLEI
ORGANS
RADIOLOGY
RADIOPHARMACEUTICALS
RADIOTHERAPY
RBE
SIMULATION
SPATIAL DISTRIBUTION
STABLE ISOTOPES
THERAPY