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High incidence of vesicoureteric reflux in asymptomatic siblings of children with known reflux

Conference · · J. Nucl. Med.; (United States)
OSTI ID:7031649
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A significant occurrence of vesicoureteric reflux in siblings of children with reflux has been previously suggested. The purpose of this study was to evaluate the incidence of vesicoureteric reflux in asymptomatic siblings of children with vesicoureteric reflux using radionuclide voiding cystography (RNC). A random group of 52 siblings was studied. Their ages were from 2 mos. to 13 yrs. (mean 4 yrs.). Seventy-one percent were female and 29% male, RNC was performed with the patients supine, and Tc-99m pertechnetate (2mCi/1) was infused into the bladder by catheter. A computerized gamma camera recorded the filling and voiding phase of the study at 1 frame/5 sec. Reflux was detected in 40% of the patients. It was bilateral in 17% and unilateral in 23% of the patients. Reflux was identified to the renal pelves in half of the patients. In two of these patients Tc-99m DMSA scans were obtained which revealed significant renal scarring. This study demonstrates the high incidence of reflux of various degrees in these asymptomatic siblings on high risk of developing significant renal disease. Identification and proper treatment of asymptomatic children with vesicoureteric reflux may help prevent the development of renal damage.

Research Organization:
The Children's Hospital and Harvard Medical School, Boston, MA
OSTI ID:
7031649
Report Number(s):
CONF-850611-
Journal Information:
J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 26:5; ISSN JNMEA
Country of Publication:
United States
Language:
English

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Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AGE GROUPS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL FUNCTIONS
BODY
CAMERAS
CHILDREN
CLEARANCE
COMPUTERIZED TOMOGRAPHY
COUNTING TECHNIQUES
DAMAGE
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DISEASE INCIDENCE
DISEASES
DRUGS
DYNAMIC FUNCTION STUDIES
EVALUATION
EXCRETION
FUNCTIONS
GAMMA CAMERAS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KIDNEYS
LABELLED COMPOUNDS
MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PEDIATRICS
PHOTON COMPUTED TOMOGRAPHY
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIONUCLIDE KINETICS
RADIOPHARMACEUTICALS
RENAL CLEARANCE
RETENTION FUNCTIONS
SCINTISCANNING
TECHNETIUM 99
TECHNETIUM ISOTOPES
TOMOGRAPHY
URINARY TRACT
UROGENITAL SYSTEM DISEASES
USES
YEARS LIVING RADIOISOTOPES