A new rapid radiobromination via transmetallation for the synthesis of radiobrominated myocardial imaging agents

Conference · Wed May 01 04:00:00 EDT 1985 · J. Nucl. Med.; (United States)

OSTI ID:7029647

Srivastava, P C; Knapp, Jr, F F; Kabalka, G W; Kunda, S A

The use of E-vinylmercury bromides as precursors for the preparation of (E,Z)-vinylradiobromides has been investigated. E-iodovinylboronic acids were treated with Hg(OAc)/sub 2/ in THF to give the mercuric acetates, which were converted to the corresponding vinylmercury bromides by reaction with NH/sub 4/Br. Addition of Br/sub 2/ (or Br/sub 2/ + NH/sub 4/ /sup 82/Br) gave instantaneously the (E,Z)-vinylbromides 4 (or (/sup 82/Br)4) analyzed by GLC, NMR and CandH. Coupling of Na-Te-(CH/sub 2/)/sub 3/-COOEt (5) with (/sup 82/Br)4 (n=11) and subsequent hydrolysis gave (E,Z)-18-(/sup 82/Br)bromo-5-tellura-17-octadecenoic acid (6) which was characterized and evaluated in rats. Compound (E,Z)-6 shows uptake and retention similar to the radioiodonated (E) analogue suggesting that the /sup 75/Br- and /sup 76/Br-labeled agents may be good candidates for PET studies.

• Research Organization: Nuclear Medicine Group, Oak Ridge National Lab. (ORNL), Oak Ridge
• DOE Contract Number: AC05-84OR21400
• OSTI ID: 7029647
• Report Number(s): CONF-850611-
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 26:5
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400700 -- Radiochemistry & Nuclear Chemistry
550602* -- Medicine-- External Radiation in Diagnostics-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ACETATES
ALKYL RADICALS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
BORON COMPOUNDS
BORONIC ACIDS
BROMIDES
BROMINATED ALIPHATIC HYDROCARBONS
BROMINATION
BROMINE 75
BROMINE 76
BROMINE COMPOUNDS
BROMINE ISOTOPES
CARBOXYLIC ACID SALTS
CARDIOVASCULAR SYSTEM
CHEMICAL ANALYSIS
CHEMICAL PREPARATION
CHEMICAL REACTION YIELD
CHEMICAL REACTIONS
CHEMISTRY
COMPUTERIZED TOMOGRAPHY
DECOMPOSITION
DIAGNOSTIC TECHNIQUES
DOSE RATES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
HALIDES
HALOGEN COMPOUNDS
HALOGENATED ALIPHATIC HYDROCARBONS
HALOGENATION
HEART
HOURS LIVING RADIOISOTOPES
HYDROLYSIS
IMAGE PROCESSING
INTERMEDIATE MASS NUCLEI
IODINATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LABELLING
LYSIS
MAMMALS
MERCURY BROMIDES
MERCURY COMPOUNDS
MERCURY HALIDES
MUSCLES
MYOCARDIUM
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC BROMINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
POSITRON COMPUTED TOMOGRAPHY
PROCESSING
QUANTITATIVE CHEMICAL ANALYSIS
RADICALS
RADIOCHEMISTRY
RADIOISOTOPES
RADIOPHARMACEUTICALS
RATS
RODENTS
SOLVOLYSIS
SYNTHESIS
TIME DEPENDENCE
TOMOGRAPHY
UPTAKE
VERTEBRATES
VINYL RADICALS
YIELDS