Liver and kidney imaging with Ga-68-labeled dihydroxyanthraquinones. [Man, rats, dogs]

Conference · Wed Oct 01 04:00:00 EDT 1980 · J. Nucl. Med.; (United States)

OSTI ID:7028788

Schuhmacher, J; Maier-Borst, W; Wellman, H N

This paper describes the preparation of alizarin (1,2-dihydroxyanthraquinone) and alizarin red S (sodium 1,2-dihydroxyanthraquinone-3-sulfonate) labeled with Ga-68, which is obtained from a new high-yield Ge-68 ..-->.. Ga-68 generator. The uptake of Ga-68 alizarin by liver and spleen RES was studied in rats, dogs, and humans, and amounted to 80 to 85% of the administered dose within 5 min after i.v. injection. Gallium-68 alizarin red S was preferentially accumulated in the renal parenchyma to an extent of 70% within 2 hr after i.v. administration. Complete labeling of 1 mCi Ga-68 was achieved by 100 ..mu..g of each compound, amounts that are without any known measurable harm to humans.

• OSTI ID: 7028788
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 21:10
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400702 -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
560171* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Man-- (-1987)
560172 -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALIZARIN
ALKALI METAL COMPOUNDS
ANIMALS
ANTHRAQUINONES
AROMATICS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CHEMICAL PREPARATION
COMPARATIVE EVALUATIONS
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DOGS
DRUGS
DYES
GALLIUM 68
GALLIUM ISOTOPES
GLANDS
HOURS LIVING RADIOISOTOPES
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
ISOTOPES
KIDNEYS
LABELLED COMPOUNDS
LIVER
MAMMALS
MAN
MATERIALS
MEASURING INSTRUMENTS
NAI DETECTORS
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
PRIMATES
QUINONES
RADIATION DETECTORS
RADIOACTIVE MATERIALS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIONUCLIDE KINETICS
RADIOPHARMACEUTICALS
RATS
REAGENTS
RODENTS
SCINTILLATION COUNTERS
SCINTISCANNING
SODIUM COMPOUNDS
SOLID SCINTILLATION DETECTORS
SPLEEN
SYNTHESIS
VERTEBRATES