N-isopropyl-(/sup 123/I)p-iodoamphetamine: single-pass brain uptake and washout; binding to brain synaptosomes; and localization in dog and monkey brain

Conference · Wed Oct 01 00:00:00 EDT 1980 · J. Nucl. Med.; (United States)

OSTI ID:7028643

Winchell, H S ^[1]; Horst, W D; Braun, L; Oldendorf, W H; Hattner, R; Parker, H

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1. Medi-Physics, Inc., Emeryville, CA

The kinetics of N-isopropyl-p-(/sup 123/I)iodoamphetamine in rat brains were determined by serial measurements of brain uptake index (BUI) after intracarotid injection; also studied were its effects on amine uptake and release in rat's brain cortical synaptosomes; and its in vivo distribution in the dog and monkey. No specific localization in brain nuclei of the dog was seen, but there was progressive accumulation in the eyes. Rapid initial brain uptake in the ketamine-sedated monkey was noted, and further slow brain uptake occurred during the next 20 min but without retinal localization. High levels of brain activity were maintained for several hours. The quantitative initial single-pass clearance of the agent in the brain suggests its use in evaluation of regional brain perfusion. Its interaction with brain amine-binding sites suggests its possible application in studies of cerebral amine metabolism.

• OSTI ID: 7028643
• Journal Information: J. Nucl. Med.; (United States), Vol. 21:10; Conference: 28. annual meeting of the Society of Nuclear Medicine, Las Vegas, NV, USA, 16 Jun 1981
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
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AMINES
METABOLISM
BIOLOGICAL ACCUMULATION
TIME DEPENDENCE
BRAIN
RADIONUCLIDE KINETICS
SCINTISCANNING
IODINE 123
LIVER
LUNGS
NERVE CELLS
RADIOPHARMACEUTICALS
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MONKEYS
SEROTONIN
ANIMAL CELLS
ANIMALS
AROMATICS
AZOLES
BETA DECAY RADIOISOTOPES
BODY
BODY AREAS
CENTRAL NERVOUS SYSTEM
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
FACE
GLANDS
HEAD
HETEROCYCLIC COMPOUNDS
HOURS LIVING RADIOISOTOPES
HYDROXY COMPOUNDS
INDOLES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MATERIALS
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PHENOLS
POLYPHENOLS
PRIMATES
PYRROLES
RADIOACTIVE MATERIALS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RESPIRATORY SYSTEM
RESPONSE MODIFYING FACTORS
SENSE ORGANS
SOMATIC CELLS
SYMPATHOMIMETICS
TRYPTAMINES
USES
VERTEBRATES
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