Effect of bronchopulmonary lavage on lung retention and clearance of particulate material in hamsters

Journal Article · Wed Jul 01 00:00:00 EDT 1992 · Environmental Health Perspectives; (United States)

DOI:https://doi.org/10.1289/ehp.9297209· OSTI ID:7027362

Ellender, M; Hodgson, A; Wood, K L; Moody, J C ^[1]

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1. National Radiological Protection Board, Chilton (United Kingdom)

Hamsters were exposed to an aerosol of fused aluminosilicate particles (FAP) labeled with [sup 57]CO. Three groups of animals were given bronchopulmonary lavage, beginning at either 1 week, 1 month, or 6 months after exposure. Each treated group was lavaged eight times over a period of 25 days. Each lavage involved 10 saline washes of the lungs. For each group, about 60-70% of the body content of [sup 57]CO at the start of lavage treatment was removed; nearly half of this was recovered in the first two lavages. A positive correlation was demonstrated between the macrophage content and [sup 57]Co activity of the washings. The subsequent fractional clearance rate of [sup 57]Co from lavaged animals was not significantly different from that in a group of untreated control animals. 30 refs., 2 figs., 2 tabs.

• OSTI ID: 7027362
• Journal Information: Environmental Health Perspectives; (United States), Vol. 97; ISSN 0091-6765
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
COBALT 60
LUNG CLEARANCE
RETENTION
LAVAGE
RESPONSE MODIFYING FACTORS
HAMSTERS
LUNGS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CLEARANCE
COBALT ISOTOPES
EXCRETION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-ODD NUCLEI
ORGANS
RADIOISOTOPES
RESPIRATORY SYSTEM
RODENTS
VERTEBRATES
YEARS LIVING RADIOISOT
560150* - Radiation Effects on Animals
550200 - Biochemistry
550500 - Metabolism