Retrograde transport of (/sup 3/H)-D-aspartate label by cochlear and vestibular efferent neurons

Journal Article · Thu Dec 31 23:00:00 EST 1987 · Am. J. Otolaryngol.; (United States)

DOI:https://doi.org/10.1016/S0196-0709(88)80002-4· OSTI ID:7025535

Schwarz, D W; Schwarz, I E

(/sup 3/H)-D-aspartic acid was injected into the inner ear of rats. After a six hour survival time, labeled cells were found at all locations known to contain efferent cochlear or vestibular neurons. Most labeled neurons were found in the ipsilateral lateral superior olivary nucleus (LSO), although both ventral nuclei of the trapezoid body (VTB), group E, and the caudal pontine reticular nucleus (CPR) just adjacent to the ascending limb of the facial nerve also contained labeled cells. Because not all efferent neurons in the rat could be previously shown to be cholinergic, aspartate and glutamate are efferent transmitter candidates.

• Research Organization: Univ. of British Columbia, Vancouver (Canada)
• OSTI ID: 7025535
• Journal Information: Am. J. Otolaryngol.; (United States), Journal Name: Am. J. Otolaryngol.; (United States) Vol. 9:1; ISSN AJOTD
• Country of Publication: United States
• Language: English

Related Subjects

551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AMINO ACIDS
ANIMAL CELLS
ANIMALS
ASPARTIC ACID
BODY
CARBOXYLIC ACIDS
CELL CONSTITUENTS
CELL NUCLEI
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MEMBRANE TRANSPORT
NERVE CELLS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RATS
RODENTS
SENSE ORGANS
SOMATIC CELLS
SURVIVAL TIME
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES
VESTIBULAR APPARATUS