Resistance to infection with Eimeria vermiformis in mouse radiation chimeras is determined by donor bone-marrow cells

Journal Article · Sun May 01 00:00:00 EDT 1988 · Infect. Immun.; (United States)

OSTI ID:7025079

Joysey, H S; Wakelin, D; Rose, M E

The course of infection with Eimeria vermiformis was determined in BALB/b, BALB/c, and C57BL/10ScSn (B10) mice and in radiation chimeras prepared from the H-2-compatible BALB/b and B10 mice. The BALB strains, irrespective of H-2 haplotype, were resistant, the B10 mice were susceptible, and in the chimeras infection was characterized by the genotype of the donated bone-marrow cells and not by the phenotype of the recipient. Thus, the genetic control of relative resistance or susceptibility to infection with this parasite is expressed through bone-marrow-derived cells.

• Research Organization: Institute for Animal Health, Huntingdon (England)
• OSTI ID: 7025079
• Journal Information: Infect. Immun.; (United States), Journal Name: Infect. Immun.; (United States) Vol. 56:5; ISSN INFIB
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
BONE MARROW CELLS
CHIMERAS
CONNECTIVE TISSUE CELLS
GENOTYPE
IMMUNITY
INFECTIVITY
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MATERIALS
MICE
MOSAICISM
PARASITES
PHENOTYPE
RADIATION CHIMERAS
RODENTS
SOMATIC CELLS
VERTEBRATES