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Go/no-go discriminated avoidance learning in prenatally x-irradiated rats

Journal Article · · Neurotoxicol. Teratol.; (United States)
;
Male Fischer344 rats were exposed to x-irradiation at a dose of 200 rad on Day 17 of gestation. Irradiated and control rats were tested at 10-13 weeks of age with the paradigm of go/no-go (active-passive) discriminated avoidance conditioning for three consecutive daily sessions. During the first conditioning session, they learned only active avoidance responses to two different warning signals. During the second and third sessions, they learned active and passive avoidance responses: in response to one warning signal, rats were required to make an active response to avoid a shock, but not to run in response to the other signal in order to avoid a shock. Prenatally irradiated rats made more active avoidance responses to both warning signals than controls (first session). In the early training phase of the go/no-go task, irradiated rats performed significantly higher active and lower passive avoidance responses than controls. Irradiated rats established a strong tendency to respond actively to the no-go signal, but eventually learned to respond to it.
Research Organization:
Shinshu Univ., Nagano (Japan)
OSTI ID:
7025031
Journal Information:
Neurotoxicol. Teratol.; (United States), Journal Name: Neurotoxicol. Teratol.; (United States) Vol. 10:1; ISSN NETEE
Country of Publication:
United States
Language:
English

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Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BEHAVIOR
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
DOSES
ELECTROMAGNETIC RADIATION
HIPPOCAMPUS
IONIZING RADIATIONS
LEARNING
MAMMALS
NERVOUS SYSTEM
ORGANS
PRENATAL EXPOSURE
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RATS
RODENTS
VERTEBRATES
X RADIATION