Effect of continuous infusion of bleomycin on repopulation in mouse lip mucosa during fractionated irradiation

Journal Article · Fri Jan 01 04:00:00 EST 1988 · NCI Monogr.; (United States)

OSTI ID:7025013

Vanuytsel, L; Feng, Y; Landuyt, W; van der Schueren, E

The effect of the administration of bleomycin on repopulation in mouse lip mucosa during fractionated irradiation was studied. Two equal-sized irradiation fractions were delivered with 1-, 7-, or 10-day intervals, with and without simultaneous administration of 40 mg bleomycin/kg in a continuous sc infusion, given over 7 days. In the experiments with irradiation only, the prolongation of the interval from 1 day to 7 days resulted in a net increase of the isoeffective dose due to compensatory proliferation. This effect was even more pronounced with the 10-day treatment interval. The addition of bleomycin, however, nearly completely suppressed this proliferative activity.

• Research Organization: University Hospital St. Rafael, Leuven (Belgium)
• OSTI ID: 7025013
• Journal Information: NCI Monogr.; (United States), Journal Name: NCI Monogr.; (United States) Vol. 6; ISSN NCIME
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
ANTIMITOTIC DRUGS
ANTINEOPLASTIC DRUGS
BLEOMYCIN
CELL PROLIFERATION
COMBINED THERAPY
DIGESTIVE SYSTEM
DOSE-RESPONSE RELATIONSHIPS
DRUGS
FRACTIONATED IRRADIATION
IRRADIATION
MAMMALS
MEMBRANES
MICE
MUCOUS MEMBRANES
ORAL CAVITY
RADIOSENSITIVITY EFFECTS
RODENTS
THERAPY
VERTEBRATES