Randomized study of zinc supplementation during pregnancy

Conference · Wed Mar 05 04:00:00 EST 1986 · Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)

OSTI ID:7024522

Hambidge, K M; Oliva-Rasbach, J; Jacobs, M; Purcell, S; Statland, C; Poirier, J

The hypothesis underlying this study was that a daily dietary Zn supplement during pregnancy would be associated with higher values for selected indices of Zn nutriture than corresponding values for non-Zn-supplemented subjects, if, and only if, Zn status of the unsupplemented control group was sub-optimal. The 12 test and 17 control subjects were healthy, apparently well-nourished anglos who were enrolled before the 12th week of gestation. Mean age=29 yrs, mean parity=0.8. Test subjects received a daily supplement of 15 mg Zn (mean compliance=90%) from the time of enrollment until 3 months post-partum. The supplement was taken at bedtime while other vitamin/mineral preparations were taken before breakfast. Blood samples were obtained at 4 week intervals from enrollment. Selected preliminary results: plasma Zn declined progressively with length of gestation to a nadir of 53 +/- 6 ..mu..g/dl at 10 months. (Non-pregnant mean 77 +/- 7). As in a previous, non-randomized, study the rate of decline for the test group did not differ from that of the control group. Mean monthly neutrophil Zn ranged from 43 +/- 8 - 50 +/- 14 ..mu..g/10/sup 10/ cells; there was not consistent pattern across gestation. Serum alkaline phosphatase activity and pre-albumin of the test group did not differ from the control group. These data did not give any indication of sub-optimal Zn nutriture in this pregnant population.

• Research Organization: Univ. of Colorado, Denver
• OSTI ID: 7024522
• Report Number(s): CONF-8604222-
• Conference Information: Journal Name: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States) Journal Volume: 45:4
• Country of Publication: United States
• Language: English

Related Subjects

550500* -- Metabolism
59 BASIC BIOLOGICAL SCIENCES
ALKALINE PHOSPHATASE
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
ELEMENTS
ENZYME ACTIVITY
ENZYMES
ESTERASES
HYDROLASES
LEUKOCYTES
MAMMALS
MAN
MATERIALS
METABOLISM
METALS
NEUTROPHILS
NUTRITION
PHOSPHATASES
PREGNANCY
PRIMATES
VERTEBRATES
ZINC