Spermatogenic and mutagenic damage after paternal exposure to systemic indium-114m

Journal Article · Mon Aug 01 04:00:00 EDT 1994 · Radiation Research

DOI:https://doi.org/10.2307/3578663· OSTI ID:70233

Hoyes, K P; Hendry, J H ^[1]; Sharma, H L; Jackson, H; Morris, I D ^[2]

---

1. Paterson Institute for Cancer Research, Manchester (United Kingdom)
2. Univ. of Manchester (United Kingdom)

The cytotoxic and mutagenic consequences of systemic administration of {sup 114m}In have been examined. Adult male rats were dosed intraperitoneally with 14.8 or 3.7 MBq/kg {sup 114m}In. Approximately 0.25% of the injected radioactivity was localized within the testis by 24 h and was retained with an effective half-life of 49.5 days. Breeding studies were started 3 days after injection, males being housed with two females for seven consecutive mating trials of 19 days, separated by 2 days. Indium-114m caused a reduction in litter size and an increase in the incidence of pre- and postimplantation losses and dominant lethal mutations. These effects became evident from 24 days but were most marked between 87-126 days after treatment and persisted up to 147 days. When animals were mated 200 days after treatment, no significant changes were observed. In a parallel study, administration of 14.8 MBq/kg {sup 114m}In resulted in decreased testis and epididymal weight and sperm reserves. Maximal reduction occurred between 87-108 days after injection followed by recovery toward control values, but neither organ had reached normal levels at 200 days. A single dose of 3.7 MBq/kg, however, had no effect on reproductive organ weight or sperm content. Male F{sub 1} progeny from the 14.8 MBq/kg group of the second mating period (commencing at 24 days) displayed decreased testis weights and sperm content and provoked a higher incidence of dominant lethal mutations. This effect was not observed in male progeny from any other time or the alternative dose level. 43 refs., 4 figs., 3 tabs.

• Sponsoring Organization: USDOE
• OSTI ID: 70233
• Journal Information: Radiation Research, Journal Name: Radiation Research Journal Issue: 2 Vol. 139; ISSN RAREAE; ISSN 0033-7587
• Country of Publication: United States
• Language: English

Related Subjects

56 BIOLOGY AND MEDICINE
APPLIED STUDIES
BIOLOGICAL HALF-LIFE
BIOLOGICAL LOCALIZATION
BIOLOGICAL RADIATION EFFECTS
BREEDING
GENETIC RADIATION EFFECTS
INDIUM 114
LETHAL MUTATIONS
LITTER SIZE
MALES
RADIOACTIVITY
RADIONUCLIDE ADMINISTRATION
RADIONUCLIDE KINETICS
RATS
TESTES