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Regulation of serotonin release from enterochromaffin cells of rat cecum mucosa

Journal Article · · Journal of Pharmacology and Experimental Therapeutics; (USA)
OSTI ID:7016442
;  [1]
  1. INSERM U6-CNRS, URA 142, Marseille (France)
+ Show Author Affiliations
The release of endogenous serotonin or previously taken up tritiated serotonin from isolated strips of rat cecum mucosa containing enterochromaffin cells was studied in vitro. Release of tritiated serotonin was increased by potassium depolarization and was decreased by tetrodotoxin, veratridine and the absence of calcium. Endogenous serotonin was released at a lower rate than tritiated serotonin; endogenous serotonin release was stimulated by potassium depolarization but was unaffected by tetrodotoxin, veratridine or the absence of calcium. Carbachol, norepinephrine, clonidine and isoproterenol decreased release of tritiated serotonin but had less or reverse effect on release of endogenous serotonin. The results suggest two different serotoninergic pools within the enterochromaffin cell population.
OSTI ID:
7016442
Journal Information:
Journal of Pharmacology and Experimental Therapeutics; (USA), Journal Name: Journal of Pharmacology and Experimental Therapeutics; (USA) Vol. 253:2; ISSN 0022-3565; ISSN JPETA
Country of Publication:
United States
Language:
English

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550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALKALI METALS
AMINES
ANIMAL CELLS
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
AZAARENES
AZOLES
BIOCHEMICAL REACTION KINETICS
BODY
CELL CULTURES
DIGESTIVE SYSTEM
DRUGS
ELEMENTS
GASTROINTESTINAL TRACT
HETEROCYCLIC COMPOUNDS
HYDROGEN COMPOUNDS
HYDROXY COMPOUNDS
INDOLES
INTESTINES
ISOTOPE APPLICATIONS
KINETICS
LARGE INTESTINE
MAMMALS
MEMBRANES
METALS
MUCOUS MEMBRANES
NEUROREGULATORS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
POTASSIUM
PYRROLES
RADIOPROTECTIVE SUBSTANCES
RATS
REACTION KINETICS
RODENTS
SECRETION
SEROTONIN
SYMPATHOMIMETICS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
TRYPTAMINES
VERTEBRATES