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The human enamel protein gene amelogenin is expressed from both the X and the Y chromosomes

Journal Article · · American Journal of Human Genetics; (United States)
OSTI ID:7014043
 [1]; ; ;  [2];  [3]
  1. Faculty of Medicine, La Laguna (Spain)
  2. University of California School of Medicine, Torrence (United States)
  3. Lawrence Livermore National Laboratory, CA (United States)
+ Show Author Affiliations

Amelogenins, a family of extracellular matrix proteins of the dental enamel, are transiently but abundantly expressed by ameloblasts during tooth development. In this paper the authors report the characterization of the AMGX and AMGY genes on the short arms of the human X and Y chromosomes which encode the amelogenins. Their studies on the expression of the amelogenin genes in male developing tooth buds showed that both the AMGX and AMGY genes are transcriptionally active and encode potentially functional proteins. They have isolated genomic and cDNA clones form both the AMGX and AMGY loci and have studied the sequence organization of these two genes. Reverse transcriptase (RT)PCR amplification of the 5[prime] portion of the amelogenin transcripts revealed several alternatively spliced products. This information will be useful for studying the molecular basis of X-linked amelogenesis imperfecta, for understanding the evolution and regulation of gene expression on the mammalian sex chromosomes, and for investigating the role of amelogenin genes during tooth development.

OSTI ID:
7014043
Journal Information:
American Journal of Human Genetics; (United States), Journal Name: American Journal of Human Genetics; (United States) Vol. 50:2; ISSN AJHGAG; ISSN 0002-9297
Country of Publication:
United States
Language:
English

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Related Subjects

550400* -- Genetics
59 BASIC BIOLOGICAL SCIENCES
BIOLOGICAL EVOLUTION
CHROMOSOMES
DENTIN
DIGESTIVE SYSTEM
DNA
DNA POLYMERASES
DNA SEQUENCING
ENZYMES
GENE AMPLIFICATION
GENES
GENETIC MAPPING
HETEROCHROMOSOMES
HUMAN CHROMOSOMES
HUMAN X CHROMOSOME
HUMAN Y CHROMOSOME
MAPPING
NUCLEIC ACIDS
NUCLEOTIDYLTRANSFERASES
ORAL CAVITY
ORGANIC COMPOUNDS
PHOSPHORUS-GROUP TRANSFERASES
POLYMERASES
PROTEINS
RECOMBINANT DNA
STRUCTURAL CHEMICAL ANALYSIS
TEETH
TRANSFERASES
X CHROMOSOME
Y CHROMOSOME