The mechanism of low levels of nitrogen dioxide reaction with unsaturated fatty acid esters
Thesis/Dissertation
·
OSTI ID:7013568
Nitrogen dioxide is a toxic air pollutant that exists at less than 0.5 ppm in the atmosphere. This toxic compound is known to initiate autoxidation of unsaturated fatty acids both in vivo and in vitro. When autoxidation occurs in vivo, membrane damage that can lead to cell death can occur. Low concentrations of nitrogen dioxide were shown to react with the polyunsaturated fatty acid esters, methyl linoleate and methyl linoleate, by a H-abstraction mechanism. However, methyl oleate, an unsaturated fatty acid ester, was demonstrated to react with a low concentration of nitrogen dioxide by only an addition mechanism. Although methyl oleate reacts by an addition mechanism, a 50:50 molar solution of methyl oleate and methyl linoleate reacted with a low level of nitrogen dioxide exclusively by a H-abstraction mechanism. Therefore, low levels of nitrogen dioxide will probably react with polyunsaturated fatty acid components of pulmonary lipids by a H-abstraction mechanism forming nitrous acid directly in the cell membrane. Vitamin E was demonstrated to be able to act as a preventative antioxidant in the nitrogen dioxide and methyl linoleate reactions; but vitamin C could not prevent nitrogen dioxide from reacting with methyl linoleate by a H-abstraction mechanism. These results suggest that low levels of nitrogen dioxide will react with polyunsaturated fatty acids by a H-abstraction mechanism and that vitamin E can be used to prevent the reaction from occurring.
- Research Organization:
- Louisiana State Univ. and Agricultural and Mechanical Coll., Baton Rouge, LA (United States)
- OSTI ID:
- 7013568
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
BIOLOGICAL EFFECTS
BODY
CARBOXYLIC ACIDS
CELL CONSTITUENTS
CELL MEMBRANES
CHALCOGENIDES
ESTERS
LINOLEIC ACID
LUNGS
MEMBRANES
METABOLISM
MONOCARBOXYLIC ACIDS
NITROGEN COMPOUNDS
NITROGEN DIOXIDE
NITROGEN OXIDES
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
OXIDES
OXYGEN COMPOUNDS
POLLUTION
RESPIRATORY SYSTEM
TOXICITY
VITAMIN E
VITAMINS
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
BIOLOGICAL EFFECTS
BODY
CARBOXYLIC ACIDS
CELL CONSTITUENTS
CELL MEMBRANES
CHALCOGENIDES
ESTERS
LINOLEIC ACID
LUNGS
MEMBRANES
METABOLISM
MONOCARBOXYLIC ACIDS
NITROGEN COMPOUNDS
NITROGEN DIOXIDE
NITROGEN OXIDES
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
OXIDES
OXYGEN COMPOUNDS
POLLUTION
RESPIRATORY SYSTEM
TOXICITY
VITAMIN E
VITAMINS