Radiosensitization of human bronchogenic carcinoma cells by interferon beta
Journal Article
·
· J. Interferon Res.; (United States)
The effects of interferons on the radiosensitivity of in vitro human bronchogenic carcinoma cells was investigated. Human fibroblast-derived interferon (IFN-beta) was found to sensitize cells to gamma irradiation while either HuIFN-alpha or mouse IFN-alpha/beta did not. The observed radiosensitization was supra-additive and resulted in a decrease in the shoulder width of the radiation dose-cell survival curve but did not affect the slope. The degree of radiosensitization of the various IFNs tested paralleled the antiproliferative effects of these IFNs on this cell line.
- Research Organization:
- University of Wisconsin, Madison
- OSTI ID:
- 7013567
- Journal Information:
- J. Interferon Res.; (United States), Journal Name: J. Interferon Res.; (United States) Vol. 4:1; ISSN JIRED
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BRONCHI
CARCINOMAS
CELL CULTURES
DISEASES
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
GAMMA RADIATION
INTERFERON
IONIZING RADIATIONS
MAMMALS
MAN
NEOPLASMS
PRIMATES
RADIATIONS
RADIOSENSITIVITY EFFECTS
RESPIRATORY SYSTEM
SURVIVAL CURVES
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BRONCHI
CARCINOMAS
CELL CULTURES
DISEASES
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
GAMMA RADIATION
INTERFERON
IONIZING RADIATIONS
MAMMALS
MAN
NEOPLASMS
PRIMATES
RADIATIONS
RADIOSENSITIVITY EFFECTS
RESPIRATORY SYSTEM
SURVIVAL CURVES
VERTEBRATES