Graft-versus-host disease in cyclosporin A-treated rats after syngeneic and autologous bone marrow reconstitution
Journal Article
·
· J. Exp. Med.; (United States)
Lethally irradiated rats treated with cyclosporin A (CsA) for 20-40 d develop classic graft-versus-host disease (GVHD) when reconstituted with syngeneic or autologous bone marrow, upon discontinuation of CsA, whereas normal rats do not. Syngeneic GVHD may be transferred to irradiated but not normal syngeneic recipients. Normal spleen cells fail to prevent the development or adoptive transfer of syngeneic GVHD.
- Research Organization:
- Johns Hopkins Univ., School of Medicine, Baltimore, MD
- OSTI ID:
- 7013246
- Journal Information:
- J. Exp. Med.; (United States), Journal Name: J. Exp. Med.; (United States) Vol. 158:1; ISSN JEMEA
- Country of Publication:
- United States
- Language:
- English
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Thesis/Dissertation
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·
OSTI ID:5802235
Increased incidence of murine graft-versus-host disease after allogeneic bone marrow transplantation by previous infusion of syngeneic bone marrow cells
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Related Subjects
550300 -- Cytology
560151* -- Radiation Effects on Animals-- Man
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BIOLOGICAL EFFECTS
BODY
BONE MARROW
DRUGS
GRAFT-HOST REACTION
HEMATOPOIETIC SYSTEM
IMMUNOSUPPRESSIVE DRUGS
IRRADIATION
LETHAL IRRADIATION
MAMMALS
ORGANS
RATS
RODENTS
SOMATIC CELLS
SPLEEN CELLS
TISSUES
VERTEBRATES
560151* -- Radiation Effects on Animals-- Man
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BIOLOGICAL EFFECTS
BODY
BONE MARROW
DRUGS
GRAFT-HOST REACTION
HEMATOPOIETIC SYSTEM
IMMUNOSUPPRESSIVE DRUGS
IRRADIATION
LETHAL IRRADIATION
MAMMALS
ORGANS
RATS
RODENTS
SOMATIC CELLS
SPLEEN CELLS
TISSUES
VERTEBRATES