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Perfluorochemical emulsions can increase tumor radiosensitivity

Journal Article · · Science (Washington, D.C.); (United States)
;

An oxygen-carrying perfluorochemical emulsion enhanced the effectiveness of radiation therapy in two transplantable solid tumors in mice. The perfluorochemical emulsion had no effect on tumor growth after x-irradiation, but delayed tumor growth significantly when administered to oxygen-breathing mice before or during irradiation.

Research Organization:
Dana-Farber Cancer Inst., Boston, MA
OSTI ID:
7013149
Journal Information:
Science (Washington, D.C.); (United States), Journal Name: Science (Washington, D.C.); (United States) Vol. 223:4639; ISSN SCIEA
Country of Publication:
United States
Language:
English

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Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
DISEASES
ELECTROMAGNETIC RADIATION
IONIZING RADIATIONS
MAMMALS
MEDICINE
MICE
NEOPLASMS
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANIC FLUORINE COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
RADIATIONS
RADIOLOGY
RADIOSENSITIVITY
RADIOSENSITIVITY EFFECTS
RADIOTHERAPY
RODENTS
THERAPY
TIME DEPENDENCE
VERTEBRATES
X RADIATION