Osteoradionecrosis: predisposing factors and outcomes of therapy

Journal Article · · Head Neck Surg.; (United States)

DOI:https://doi.org/10.1002/hed.2890060404· OSTI ID:7004579

Beumer, J; Harrison, R; Sanders, B; Kurrasch, M

Eighty-three episodes of osteoradionecrosis are reported. Of those episodes affecting the mandible (78), 23 (29.5%) required radical resection. The most common precipitating factors were postradiation extractions (22/83), periodontal disease (19/83), and preradiation extractions (17/83). Those episodes initially located within the zone of attached mucosa fared well with conservative measures while those initially located beyond the zone of attached mucosa fared poorly. In bone necroses where the external radiation dose to the affected bone exceeded 7,000 rad, the mandibular resection rate was high (44%). The most effective way of resolving advanced bone necroses was achieved with a course of hyperbaric oxygen therapy combined with a surgical sequestrectomy.

• Research Organization: Division of Hospital Dentistry, School of Dentistry, University of California, Los Angeles
• OSTI ID: 7004579
• Journal Information: Head Neck Surg.; (United States), Journal Name: Head Neck Surg.; (United States) Vol. 6:4; ISSN HNSUD
• Country of Publication: United States
• Language: English

Related Subjects

560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
DISEASES
DOSE-RESPONSE RELATIONSHIPS
INJURIES
JAW
LOCAL RADIATION EFFECTS
MEDICINE
NECROSIS
NUCLEAR MEDICINE
ORGANS
OSTEORADIONECROSIS
PATHOLOGICAL CHANGES
POST-IRRADIATION THERAPY
RADIATION EFFECTS
RADIATION INJURIES
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
SKELETAL DISEASES
SKELETON
SKULL
SURGERY
THERAPY