Factors affecting regional pulmonary blood flow in chronic ischemic heart disease
To assess the effect of left heart disease on pulmonary blood flow distribution, we measured mean pulmonary arterial and wedge pressures, cardiac output, pulmonary vascular resistance, pulmonary blood volume, and arterial oxygen tension before and after treatment in 13 patients with longstanding ischemic heart failure and pulmonary edema. Pulmonary edema was evaluated by a radiographic score, and regional lung perfusion was quantified on a lung scan by the upper to lower third ratio (U:L ratio) of pulmonary blood flow per unit of lung volume. In all cases, redistribution of lung perfusion toward the apical regions was observed; this pattern was not affected by treatment. After treatment, pulmonary vascular pressures, resistance, and edema were reduced, while pulmonary blood volume did not change. At this time, pulmonary vascular resistance showed a positive correlation with the U:L ratio (r = 0.78; P less than 0.01), whereas no correlation was observed between U:L ratio and wedge pressure, pulmonary edema, or arterial oxygen tension. Hence, redistribution of pulmonary blood flow, in these patients, reflects chronic structural vascular changes prevailing in the dependent lung regions.
- Research Organization:
- 2nd Univ. of Rome (Italy)
- OSTI ID:
- 7001448
- Journal Information:
- J. Thorac. Imaging.; (United States), Journal Name: J. Thorac. Imaging.; (United States) Vol. 3:3; ISSN JTIME
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
BLOOD FLOW
BLOOD PRESSURE
BODY
CARDIOVASCULAR DISEASES
COUNTING TECHNIQUES
DIAGNOSIS
DISEASES
ELEMENTS
ISCHEMIA
LUNGS
NONMETALS
ORGANS
OXYGEN
PATIENTS
PERFUSED ORGANS
RADIOISOTOPE SCANNING
RESPIRATORY SYSTEM
VASCULAR DISEASES