Dopamine uptake sites in the striatum are distributed differentially in striosome and matrix compartments

Journal Article · Wed Nov 01 04:00:00 EST 1989 · Proceedings of the National Academy of Sciences of the United States of America; (USA)

DOI:https://doi.org/10.1073/pnas.86.22.9020· OSTI ID:6999321

Graybiel, A M; Moratalla, R ^[1]

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1. Massachusetts Institute of Technology, Cambridge (USA)

A major mechanism of neurotransmitter inactivation at catecholaminergic synapses in reuptake of released transmitter at high-affinity uptake sites on presynaptic terminals. The authors have analyzed the anatomical distribution of site-selective ligand binding for dopamine uptake sites in the striatum of rat, cat, and monkey. The authors report here that desipramine-sensitive ({sup 3}H)mazindol binding sites have highly heterogeneous distributions in the dorsal and the ventral striatum. In the caudate nucleus of cat and monkey, ({sup 3}H)mazindol binding observes striosomal ordering, being reduced in striosomes and heightened in the extrastriosomal matrix. Some local heterogeneity appears in the ventral caudoputamen of the rat. Different subdivisions of the nucleus accumbens also have different binding levels. These findings suggest that some functional effects of psychoactive drugs, such as cocaine, and that bind to the dopamine-uptake complex could be related to the distribution of these specific uptake sites. The findings also raise the possibility that these distributions could result in selective neuronal vulnerability to neurotoxins, such as 1-methyl-4-phenylpyridine (MPP{sup +}), that depend on the dopamine-uptake complex for entry into neurons.

• OSTI ID: 6999321
• Journal Information: Proceedings of the National Academy of Sciences of the United States of America; (USA), Journal Name: Proceedings of the National Academy of Sciences of the United States of America; (USA) Vol. 86:22; ISSN 0027-8424; ISSN PNASA
• Country of Publication: United States
• Language: English

Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AMINES
ANIMALS
ANTIGENS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOCHEMISTRY
BODY
BRAIN
CARDIOTONICS
CARDIOVASCULAR AGENTS
CATS
CENTRAL NERVOUS SYSTEM
CHEMISTRY
CYTOCHEMISTRY
DISTRIBUTION
DOPAMINE
DRUGS
HYDROGEN COMPOUNDS
HYDROXY COMPOUNDS
INACTIVATION
MAMMALS
MATERIALS
MEMBRANE PROTEINS
MONKEYS
NERVOUS SYSTEM
NEUROREGULATORS
ORGANIC COMPOUNDS
ORGANS
PHENOLS
POLYPHENOLS
PRIMATES
PROTEINS
RATS
RECEPTORS
RODENTS
SYMPATHOMIMETICS
TISSUE DISTRIBUTION
TOXIC MATERIALS
TOXINS
TRITIUM COMPOUNDS
UPTAKE
VERTEBRATES