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Visualization of multiple opioid-receptor types in rat striatum after specific mesencephalic lesions

Journal Article · · Proc. Natl. Acad. Sci. U.S.A.; (United States)
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In order to gain insight into a possible modulatory role for ..mu.., delta, and kappa opioid receptors of the nigrostriatal dopaminergic pathway, the authors investigated the topographical organization of the receptors with respect to pre- and postsynaptic membranes. Dopaminergic terminals projecting from the substantia nigra to the corpus striatum were destroyed by unilateral injection of 6-hydroxydopamine into the susbstantia nigra. Quantitative receptor assays using highly specific radioligands were used to measure the density of striatal ..mu.., delta, and kappa receptors before and after denervation. Quantitative in vitro autoradiography was used to visualize the neuroanatomical pattern of receptors on lesioned and nonlesioned sides of the brain under the light microscope. Loss of ..mu.. receptors in striatal patches was striking in the ventro-lateral areas of the striatum, whereas the most notable loss of delta receptors was found in the central striatum. Other brain areas did not differ significantly in ..mu.. receptor density between the lesioned and nonlesioned sides, as determined by autoradiography. These findings suggest that a high percentage of ..mu.. and delta receptors in the striatum are located on the nigrostriatal dopaminergic terminals and support the concept of a modulatory role for ..mu.. and delta opioid peptides in the nigrostriatal dopaminergic pathway.
Research Organization:
Albert Einstein College of Medicine, Bronx, NY (USA)
OSTI ID:
6998987
Journal Information:
Proc. Natl. Acad. Sci. U.S.A.; (United States), Journal Name: Proc. Natl. Acad. Sci. U.S.A.; (United States) Vol. 84:18; ISSN PNASA
Country of Publication:
United States
Language:
English

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Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINES
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
AUTORADIOGRAPHY
BODY
BRAIN
CARDIOTONICS
CARDIOVASCULAR AGENTS
CENTRAL NERVOUS SYSTEM
CONFIGURATION INTERACTION
DISTRIBUTION
DOPAMINE
DRUGS
ENDORPHINS
ENKEPHALINS
HYDROXY COMPOUNDS
LABELLED COMPOUNDS
LIGANDS
MEMBRANE PROTEINS
MICROSCOPY
NERVOUS SYSTEM
NEUROREGULATORS
ORGANIC COMPOUNDS
ORGANS
PEPTIDES
PHENOLS
POLYPEPTIDES
POLYPHENOLS
PROTEINS
RECEPTORS
SYMPATHOMIMETICS
TISSUE DISTRIBUTION
TRITIUM COMPOUNDS