Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Genotoxicity of organic extracts from atmospheric particles

Journal Article · · Ann. N.Y. Acad. Sci.; (United States)
; ; ; ; ;

Experiments to evaluate the genotoxic potentialities of urban air particles sampled in Paris (France) after organic solvent extraction have been carried out using four in vitro genotoxicity tests. The two bacterial tests (the Ames test and the SOS Chromotest) demonstrate the genotoxicity of the organic extracts of atmospheric particles; two additional tests (induction of 6-thioguanine mutants and sister chromatid exchanges), carried out on V79 Chinese hamster cells, also confirm these potentialities. These results show clearly that particulate organic extracts induce point mutations in both bacteria and mammalian cells, or the cellular response (SOS repair) to these mutations in bacteria; likewise, they are responsible for clastogenic effects in mammalian cells. Genotoxicity is due either to direct genotoxic chemicals or to active metabolic products of the action of microsomal enzymes. The optimalization of testing procedures is discussed in order to appreciate the contribution of genotoxicity tests to the study of atmospheric pollution.

Research Organization:
Laboratoire d'Hygiene de la Ville de Paris (France)
OSTI ID:
6998744
Journal Information:
Ann. N.Y. Acad. Sci.; (United States), Journal Name: Ann. N.Y. Acad. Sci.; (United States) Vol. 534; ISSN ANYAA
Country of Publication:
United States
Language:
English

Similar Records

[Toxicity studies of mild gasification products: Quarterly technical progress report, April--June 1993]
Technical Report · Thu Dec 30 23:00:00 EST 1993 · OSTI ID:10117563
Genotoxic activity of particulate material in petroleum refinery effluents
Journal Article · Thu Aug 01 00:00:00 EDT 1985 · Bull. Environ. Contam. Toxicol.; (United States) · OSTI ID:6460372
The genotoxicity studies of mild gasification product, MRE{number_sign}1, in mammalian cells. [Quarterly technical progress report, July 1, 1993--September 30, 1993]
Technical Report · Thu Dec 30 23:00:00 EST 1993 · OSTI ID:10119402

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
ANIMAL CELLS
BACTERIA
BIOLOGICAL EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CELL CONSTITUENTS
CHO CELLS
CHROMOSOMAL ABERRATIONS
DNA REPAIR
EUROPE
EXTRACTION
FRANCE
GENETIC EFFECTS
METABOLIC ACTIVATION
MICROORGANISMS
MICROSOMES
MUTAGEN SCREENING
MUTATIONS
ORGANOIDS
PARTICLE SIZE
PARTICLES
PARTICULATES
POLLUTION
RECOVERY
REPAIR
SALMONELLA
SCREENING
SEPARATION PROCESSES
SISTER CHROMATID EXCHANGES
SIZE
SOLUBILITY
SOLVENT EXTRACTION
TOXICITY
URBAN AREAS
WESTERN EUROPE