Independent benzodiazepine and beta-carboline binding sites in the brain of aggressive and timid-defensive mice
Journal Article
·
· Bull. Exp. Biol. Med. (Engl. Transl.); (United States)
The authors study the distribution of specific binding sites of labeled benzodiazepine and beta-carboline derivatives in parts of the brain of intact aggressive and timid-defensive mice, and also of animals subjected to subchronic administration of diazepam. The concentrations of /sup 3/H-flunitrazepam and /sup 3/H-beta-carboline-3-carboxylate ethyl ester in the incubation mixture for binding are given. Analysis of their specific binding with brain membranes of animals not receiving diazepam showed that the concentration of specific binding sites for both ligands in both types of mice was significantly higher in the cortex than in other brain regions.
- Research Organization:
- Institute of Pharmacology, Moscow (USSR)
- OSTI ID:
- 6998123
- Journal Information:
- Bull. Exp. Biol. Med. (Engl. Transl.); (United States), Journal Name: Bull. Exp. Biol. Med. (Engl. Transl.); (United States) Vol. 103:6; ISSN BEXBA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550101 -- Behavioral Biology-- Tracer Techniques
550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANIMALS
BEHAVIOR
BIOCHEMISTRY
BIOLOGICAL EFFECTS
BODY
BRAIN
CELL CULTURES
CENTRAL NERVOUS SYSTEM
CHEMISTRY
COMPARATIVE EVALUATIONS
COUNTING TECHNIQUES
DRUGS
INJECTION
INTAKE
INTRAPERITONEAL INJECTION
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LABELLING
MAMMALS
MEMBRANE PROTEINS
MICE
NERVE CELLS
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANS
PROTEINS
PSYCHOLOGY
RADIORECEPTOR ASSAY
RECEPTORS
RODENTS
SCINTILLATION COUNTING
SOMATIC CELLS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES
550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANIMALS
BEHAVIOR
BIOCHEMISTRY
BIOLOGICAL EFFECTS
BODY
BRAIN
CELL CULTURES
CENTRAL NERVOUS SYSTEM
CHEMISTRY
COMPARATIVE EVALUATIONS
COUNTING TECHNIQUES
DRUGS
INJECTION
INTAKE
INTRAPERITONEAL INJECTION
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LABELLING
MAMMALS
MEMBRANE PROTEINS
MICE
NERVE CELLS
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANS
PROTEINS
PSYCHOLOGY
RADIORECEPTOR ASSAY
RECEPTORS
RODENTS
SCINTILLATION COUNTING
SOMATIC CELLS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES