Acute dermal toxicity of guanidine hydrochloride in rabbits. Report for 18 May-1 August 1984
Technical Report
·
OSTI ID:6998121
The acute dermal toxicity of guanidine hydrochloride was evaluated in five male and five female New Zealand White rabbits. Guanidine hydrochloride (2 g/kg) was applied topically to the clipped dorsal skin surface for 24 hours. No compound-related deaths or clinical signs were observed; however, guanidine hydrochloride did produce dermal irritation, necrosis, and eschar formation under conditions of the study.
- Research Organization:
- Letterman Army Inst. of Research, San Francisco, CA (USA)
- OSTI ID:
- 6998121
- Report Number(s):
- AD-A-217345/8/XAB; LAIR--419
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BODY
CARBONIC ACID DERIVATIVES
GUANIDINES
MAMMALS
NECROSIS
NITRO COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PROPELLANTS
RABBITS
SKIN
TOXICITY
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BODY
CARBONIC ACID DERIVATIVES
GUANIDINES
MAMMALS
NECROSIS
NITRO COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PROPELLANTS
RABBITS
SKIN
TOXICITY
VERTEBRATES