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Title: Acute dermal toxicity of guanidine hydrochloride in rabbits. Report for 18 May-1 August 1984

Technical Report ·
OSTI ID:6998121
; ;

The acute dermal toxicity of guanidine hydrochloride was evaluated in five male and five female New Zealand White rabbits. Guanidine hydrochloride (2 g/kg) was applied topically to the clipped dorsal skin surface for 24 hours. No compound-related deaths or clinical signs were observed; however, guanidine hydrochloride did produce dermal irritation, necrosis, and eschar formation under conditions of the study.

Research Organization:
Letterman Army Inst. of Research, San Francisco, CA (USA)
OSTI ID:
6998121
Report Number(s):
AD-A-217345/8/XAB; LAIR-419
Country of Publication:
United States
Language:
English

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Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
NITRO COMPOUNDS
TOXICITY
PROPELLANTS
SKIN
NECROSIS
GUANIDINES
RABBITS
ANIMALS
BODY
CARBONIC ACID DERIVATIVES
MAMMALS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology