Methylated polynuclear aromatic hydrocarbons: Structural requirements for mutagenic and tumorigenic activity: Final progress report, 9-1-82 to 10-31-86
Methylated polynuclear aromatic hydrocarbons (PAH) often possess exceptional mutagenic and carcinogenic activity which would not have been anticipated on the basis of the activities of their unsubstituted parent hydrocarbons. Whereas minor amounts of these compounds are generally formed as combustion by-products, significantly higher levels have been found in shale and coal-derived oils. This observation and the fact that subfractions rich in methylated PAH are carcinogenic in laboratory animals prompted this study of the potential effect on health of methylated PAH. The structural features of methylated tri- and tetracyclic PAH which determine their mutagenic and/or tumorigenic potential were sought and their role in the carcinogenicity of energy-related materials was studied. Methylated fluorenes, anthracenes, phenanthrenes, and pyrenes were synthesized and used to assay mutagenicity with respect to molecular structure in S. typhimurium strains TA 98, and TA 100. 54 refs., 35 figs.
- Research Organization:
- American Health Foundation, Valhalla, NY. Naylor Dana Inst. for Disease Prevention
- DOE Contract Number:
- AC02-82ER60080
- OSTI ID:
- 6997833
- Report Number(s):
- DOE/ER/60080-1; ON: DE87003414
- Resource Relation:
- Other Information: Portions of this document are illegible in microfiche products
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ALKYLATED AROMATICS
MUTAGENESIS
STRUCTURE-ACTIVITY RELATIONSHIPS
ANTHRACENE
FLUORENE
PHENANTHRENE
POLYCYCLIC AROMATIC HYDROCARBONS
PYRENE
MICE
PHORBOL ESTERS
SKIN ABSORPTION
ABSORPTION
ANIMALS
AROMATICS
CARCINOGENS
CONDENSED AROMATICS
ESTERS
HYDROCARBONS
MAMMALS
ORGANIC COMPOUNDS
RODENTS
UPTAKE
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology