Volatile N-nitrosamines in infant pacifiers sold in the United States as determined by gas chromatography/thermal energy analysis

Conference · · J. Assoc. Off. Anal. Chem.; (United States)

OSTI ID:6997268

Billedeau, S M; Thompson, Jr, H C; Miller, B J; Wind, M L

Volatile N-nitrosamines in infant latex rubber pacifiers were determined using a modification of a previously described dichloromethane extraction procedure, followed by gas chromatography/thermal energy analysis. Under an interagency agreement between the National Center for Toxicological Research and the Consumer Product Safety Commission (CPSC), data were obtained on the baseline and compliance concentrations of volatile N-nitrosamines in infant pacifiers sold in the United States. Pacifiers made by 18 different manufactures before and after the January 1, 1984 action level of 60 ppb was set by the CPSC were analyzed for volatile N-nitrosamines. N-Nitrosodibutylamine was the principal N-nitrosamine found, along with trace amounts of N-nitrosodimethylamine, N-nitrosodiethylamine, and N-nitrosopiperidine. Mean total volatile N-nitrosamine levels for baseline and compliance samples were 63.9 and 21.2 ppb, respectively. The pacifier lots sampled after January 1, 1984 showed a significant decrease in contamination levels, indicating that at least 98% of the market share is in compliance with CPSC enforcement policy for N-nitrosamines in infant pacifiers sold in the United States.

• Research Organization: Food and Drug Administration, Jefferson, AR
• OSTI ID: 6997268
• Conference Information: Journal Name: J. Assoc. Off. Anal. Chem.; (United States) Journal Volume: 69:1
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
400102* -- Chemical & Spectral Procedures
560300 -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE GROUPS
AMINES
CHEMICAL ANALYSIS
CHILDREN
CHROMATOGRAPHY
CONSUMER PRODUCTS
CONSUMER PROTECTION
ELASTOMERS
EXTRACTION
GAS CHROMATOGRAPHY
INFANTS
LATEX
METHYLENE CHLORIDE
NITROSAMINES
NITROSO COMPOUNDS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC POLYMERS
POLYMERS
QUANTITATIVE CHEMICAL ANALYSIS
QUANTITY RATIO
REGULATIONS
RUBBERS
SEPARATION PROCESSES
SOLVENT EXTRACTION
THERMAL ANALYSIS
TRACE AMOUNTS
VOLATILITY