Indium 111 ZCE-025 immunoscintigraphy in occult recurrent colorectal cancer with elevated carcinoembryonic antigen level

Journal Article · Thu Feb 01 00:00:00 EST 1990 · Archives of Surgery (Chicago); (USA)

DOI:https://doi.org/10.1001/archsurg.1990.01410140104017· OSTI ID:6994162

Doerr, R J; Abdel-Nabi, H; Merchant, B ^[1]

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1. Veterans Administration Medical Center, Buffalo, NY (USA)

We investigated the utility of scanning with indium 111 labeled to monoclonal antibody in 13 patients after curative resection of colorectal cancer who had elevated carcinoembryonic antigen levels and negative results of clinical workup. Each patient received 1 mg of anti-carcinoembryonic antigen monoclonal antibody type ZCE 025 labeled with 5.5 mCi of {sup 111}In, plus 9 to 39 mg of the same antibody unlabeled. Patients underwent scanning 3 to 7 days after infusion by planar and emission computed tomography. ZCE-025 monoclonal antibody imaging detected tumor recurrence or metastasis in 11 of 13 patients. In one patient the monoclonal antibody scan gave a true-negative result, and in one patient the monoclonal antibody scan failed to disclose a metachronous cecal primary. Tumor sites identified were the pelvis (2 patients), abdominal wall (2), retroperitoneum (1), lymph nodes (3); liver (2), bone (2), and lung (1). The accurate localization of colorectal carcinoma recurrences by means of {sup 111}In ZCE-025 monoclonal antibody demonstrates the usefulness of this diagnostic agent in the setting of elevated carcinoembryonic antigen level and negative results of clinical and radiologic workup.

• OSTI ID: 6994162
• Journal Information: Archives of Surgery (Chicago); (USA), Vol. 125:2; ISSN 0004-0010
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
CARCINOMAS
DIAGNOSIS
LARGE INTESTINE
METASTASES
RECTUM
CARCINOEMBRYONIC ANTIGEN
EMISSION COMPUTED TOMOGRAPHY
INDIUM 111
MONOCLONAL ANTIBODIES
PATIENTS
RADIOIMMUNOSCINTIGRAPHY
ANTIBODIES
ANTIGENS
BETA DECAY RADIOISOTOPES
BODY
COMPUTERIZED TOMOGRAPHY
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
GASTROINTESTINAL TRACT
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
INTESTINES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOIMMUNODETECTION
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCINTISCANNING
TOMOGRAPHY
TRACER TECHNIQUES
550601* - Medicine- Unsealed Radionuclides in Diagnostics