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Evaluation of indium-111-labeled anti-fibrin antibody for imaging vascular thrombi

Journal Article · · J. Nucl. Med.; (United States)
OSTI ID:6994036
; ; ; ;

Monoclonal antibody 59D8 developed by Hui et al., binds to fibrin but not fibrinogen. An /sup 111/In-labeled Fab fragment of 59D8 was studied in vitro and in animal models to evaluate its potential for imaging thrombi and emboli in man. Rabbits and dogs were used as models for studying thrombus uptake in vivo. Thrombi and emboli up to 4 days old were successfully visualized at 4-24 hr postinjection in five of eight rabbits. In dogs, 0.5-hr-old and 24-hr-old thrombi were successfully imaged at 24 hr in six of eight animals, and 3/6 of these were positive at 3-4 hr postinjection. Thrombus-to-blood ratios in the dogs averaged 7.1 +/- 1.3. The findings suggest this antibody may be useful for imaging thrombi in man.

Research Organization:
Temple Univ. School of Medicine and Hospital, Philadelphia, PA (USA)
OSTI ID:
6994036
Journal Information:
J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 29:4; ISSN JNMEA
Country of Publication:
United States
Language:
English

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Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINO ACIDS
ANIMALS
ANTIBODIES
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BIOLOGICAL MODELS
BLOOD
BLOOD CELLS
BLOOD PLATELETS
BODY FLUIDS
CARBOXYLIC ACIDS
CARDIOVASCULAR DISEASES
CHELATING AGENTS
COAGULANTS
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC USES
DISEASES
DOGS
DRUGS
DTPA
ELECTRON CAPTURE RADIOISOTOPES
FIBRIN
HEMATOLOGIC AGENTS
HEMOSTATICS
IMAGE PROCESSING
IN VITRO
INDIUM 111
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MATERIALS
MINUTES LIVING RADIOISOTOPES
MONOCLONAL ANTIBODIES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
PROCESSING
PROTEINS
RABBITS
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
SCLEROPROTEINS
THROMBOSIS
USES
VASCULAR DISEASES
VERTEBRATES