The toxicity, in vitro, of silicon carbide whiskers

Journal Article · Tue Oct 01 04:00:00 EDT 1991 · Environmental Research; (United States)

DOI:https://doi.org/10.1016/S0013-9351(05)80109-4· OSTI ID:6993069

Vaughan, G L; Jordan, J; Karr, S ^[1]

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1. Univ. of Tennessee, Knoxville (United States)

To mouse cells in culture, SiC whiskers (SiCW) and asbestos are similarly cytotoxic, disrupting cell membranes and killing cells. both shorten cell generation time, increase the rate of DNA synthesis, increase total cell DNA content, and cause a loss in growth control often associated with malignant cellular transformation. Within the narrow size range of materials examined, the amount of damage appeared to be more a function of the number of whiskers present than of their size. Silicon carbide whiskers, if mishandled, may pose a serious health hazard to humans.

• OSTI ID: 6993069
• Journal Information: Environmental Research; (United States), Journal Name: Environmental Research; (United States) Vol. 56:1; ISSN ENVRA; ISSN 0013-9351
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ASBESTOS
CARBIDES
CARBON COMPOUNDS
CELL CULTURES
CELL KILLING
CELL TRANSFORMATIONS
COMPARATIVE EVALUATIONS
DNA
DNA REPLICATION
EVALUATION
IN VITRO
MAMMALS
MICE
NUCLEIC ACID REPLICATION
NUCLEIC ACIDS
ONCOGENIC TRANSFORMATIONS
ORGANIC COMPOUNDS
RESPONSE MODIFYING FACTORS
RODENTS
SILICON CARBIDES
SILICON COMPOUNDS
TOXICITY
VERTEBRATES