Behavior of autologous indium-114m-labeled lymphocytes in patients with lymphoid cell malignancy
It has been shown that radioactive material can be localized to lymphocyte traffic areas using radiolabeled autologous lymphocytes and that /sup 114m/In deposited in such a way in rats produces a lymphopoenia by establishing a selective internal irradiation of circulating lymphocytes. The study reported here was undertaken to investigate the feasibility of using this technique in patients with lymphoid cell malignancy. Up to 22.7 MBq was administered to seven patients with active non-Hodgkin's lymphoma involving the spleen and the behavior of the radioactive material was followed over subsequent months. Estimates of the activity in peripheral blood, bone marrow, excreta samples, and of the variation in the whole-body distribution were obtained. The administered radioactive material cleared rapidly from the blood, 85% being removed within the first 30 min. There was an almost immediate uptake of most of this by the spleen and liver with less than 5% of administered activity accumulating in the bone marrow. After 48 hr, the whole-body distribution changed only slowly and there was a regular decrease of the activity in the spleen. Excretion of radioactive material occurred via both the urine and feces and amounted to less than 1% of administered activity per day. This pharmacokinetic data was used to calculate radiation absorbed doses to various organs for a standard man. It is concluded that this represents a feasible technique for the targeting of radioactive material for the treatment of lymphoid malignancy.
- Research Organization:
- Christie Hospital and Holt Radium Institute, Manchester (England)
- OSTI ID:
- 6992872
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 29:4
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
LYMPHOCYTES
BIOLOGICAL LOCALIZATION
LYMPHOMAS
RADIOTHERAPY
BLOOD COUNT
BONE MARROW
INDIUM 114
ISOMERIC NUCLEI
PATIENTS
RADIATION DOSES
SPLEEN
TISSUE DISTRIBUTION
ANIMAL CELLS
ANIMAL TISSUES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DAYS LIVING RADIOISOTOPES
DISEASES
DISTRIBUTION
DOSES
ELECTRON CAPTURE RADIOISOTOPES
HEMATOPOIETIC SYSTEM
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LEUKOCYTES
MATERIALS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-ODD NUCLEI
ORGANS
RADIOISOTOPES
RADIOLOGY
SECONDS LIVING RADIOISOTOPES
SOMATIC CELLS
THERAPY
TISSUES
550604* - Medicine- Unsealed Radionuclides in Therapy- (1980-)