Can historical controls be used in current clinical trials in osteosarcoma. Metastases and survival in a historical and a concurrent group

Journal Article · Mon Dec 01 04:00:00 EST 1980 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(80)90258-8· OSTI ID:6984842

Brostroem, L A ^[1]; Aparisi, T; Ingimarsson, S; Lagergren, C; Nilsonne, U; Strander, H; Soederberg, G

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1. Karolinska Hospital, Stockholm, Sweden

A historical group consisting of 35 patients with osteosarcoma was compared to a concurrent group of 23 patients. The treatment for the primary tumors differed only slghtly in the two groups. A more active approach was adopted for treatment of pulmonary metastases in the concurrent group. The percentage of patients not developing metastases and the survival rate in the historical group were approximately one half those for the concurrent group. An analysis of prognostic factors disclosed differences between the two groups as regards the size and histological type of the tumor. The results of the study cast doubt on the suitability of historical controls in current clinical trials conducted to ascertain the effectiveness of adjuvant therapy for osteosarcoma.

• OSTI ID: 6984842
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 6:12; ISSN IOBPD
• Country of Publication: United States
• Language: English

Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
CHEMOTHERAPY
COMPARATIVE EVALUATIONS
DIAGNOSIS
DISEASES
HISTOLOGY
MEDICINE
METASTASES
NEOPLASMS
NUCLEAR MEDICINE
OSTEOSARCOMAS
RADIOLOGY
RADIOTHERAPY
SARCOMAS
SIZE
SKELETAL DISEASES
SURGERY
SURVIVAL TIME
THERAPY