Chemotherapy-radiotherapy association in Hodgkin's disease, clinical stages IA, II/sub 2/A: results of a prospective clinical trial with 166 patients. [/sup 60/Co]
- Universite Paris VII, France
One hundred sixty-six patients with clinical stages IA, II/sub 2/A Hodgkin's disease were treated between April 1972 and December 1976 with three courses of multiagent chemotherapy (methylchlorethamine, vincristine, procarbazine, prednisone) followed by mantle irradiation - excluding mediastinum for those with initial upper cervical presentation and absence of mediastinal involvement - or inverted Y radiotherapy. With a follow-up of 12 to 84 months, the overall survival is 93.5% and the overall relapse-free survival 89.9%. With chemotherapy-radiotherapy sequence, staging laparotomy is not indicated. Results and side effects of this treatment strategy are compared with those of other treatment policies.
- OSTI ID:
- 6984831
- Journal Information:
- Cancer; (United States), Vol. 46:10
- Country of Publication:
- United States
- Language:
- English
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CHEMOTHERAPY
SIDE EFFECTS
IMMUNITY
BIOLOGICAL EFFECTS
RADIOTHERAPY
REPRODUCTION
COBALT 60
GAMMA RADIATION
HODGKINS DISEASE
IMMUNOSUPPRESSION
ONCOVIN
PATIENTS
PREDNISONE
STERILITY
SURVIVAL TIME
ADRENAL HORMONES
ALKALOIDS
ANTIMITOTIC DRUGS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
COBALT ISOTOPES
CORTICOSTEROIDS
DISEASES
DRUGS
ELECTROMAGNETIC RADIATION
GLUCOCORTICOIDS
HORMONES
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KETONES
LYMPHOMAS
MEDICINE
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
PREGNANES
RADIATIONS
RADIOISOTOPES
RADIOLOGY
STEROID HORMONES
STEROIDS
THERAPY
YEARS LIVING RADIOISOTOPES
550603* - Medicine- External Radiation in Therapy- (1980-)