Zinc protection against cadmium effects on preimplantation mice embryos

Journal Article · Sat Jul 01 00:00:00 EDT 1989 · Bulletin of Environmental Contamination and Toxicology; (USA)

DOI:https://doi.org/10.1007/BF01702245· OSTI ID:6983123

Belmonte, N M; Rivera, O E; Herkovits, J ^[1]

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1. National Univ. of Lomas de Zamora, Buenos Aires (Argentina)

Cadmium, one of the most toxic heavy metals, produces congenital malformations, developmental retardation and death in amphibians as well as in laboratory mammals. Although the development of preimplantation mammalian embryos may be impaired by environmental chemicals, it has been reported that Cd{sup ++} administered on day 3 of gestation exerts only a slight reduction in the number of blastocysts. However, the further capacity of those embryos to hold postblastocystical development was not evaluated. On the other hand, the protective role of Zn{sup ++} against several etiological agents which produce malformations including Cd{sup ++} is well documented. The present study was undertaken to investigate the effects of Cd{sup ++} administered in preimplantation stages of mouse embryos and to evaluate the eventual protective role of Zn{sup ++} against the effects of Cd.

• OSTI ID: 6983123
• Journal Information: Bulletin of Environmental Contamination and Toxicology; (USA), Vol. 43:1; ISSN 0007-4861
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CADMIUM CHLORIDES
TOXICITY
EMBRYOS
CONGENITAL MALFORMATIONS
ZINC SULFATES
BIOLOGICAL EFFECTS
CATIONS
MICE
ANIMALS
CADMIUM COMPOUNDS
CADMIUM HALIDES
CHARGED PARTICLES
CHLORIDES
CHLORINE COMPOUNDS
HALIDES
HALOGEN COMPOUNDS
IONS
MALFORMATIONS
MAMMALS
OXYGEN COMPOUNDS
PATHOLOGICAL CHANGES
RODENTS
SULFATES
SULFUR COMPOUNDS
VERTEBRATES
ZINC COMPOUNDS
560300* - Chemicals Metabolism & Toxicology