Imaging receptors and their interactions: Implications for psychiatry

Conference · Sat Dec 31 23:00:00 EST 1988

OSTI ID:6976062

Brodie, J D; Wolkin, A; Barouche, F; Rotrosen, J; Angrist, B ^[1]; Fowler, J S; Wolf, A P; Dewey, S L; Volkow, N D; MacGregor, R; Schlyer, D J; Bendriem, B ^[2]

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1. New York Univ., NY (USA). Dept. of Psychiatry
2. Brookhaven National Lab., Upton, NY (USA)

In the past ten years various receptor ligands for dopaminergic systems have been labeled and their regional distribution and time course imaged using positron emission tomography (PET). Labeled compounds have been developed to probe the opiate, benzodiazepine and serotonin receptors among others. The interest in evaluating dopamine receptors in the human brain has clearly been related to the known anti-psychotic effect of dopamine antagonists. In the present report, we shall summarize some of our recent findings on the dopamine (DA) system which bear on the psychiatric issues of the objective determination and monitoring of adequate neuroleptic dose; whether neuroleptic non-response is due to a failure of drug delivery; and preliminary data on the cholinergic system and its putative interaction with the DA system. 6 refs., 2 figs.

• Research Organization: Brookhaven National Lab., Upton, NY (USA)
• Sponsoring Organization: DOE/ER
• DOE Contract Number: AC02-76CH00016
• OSTI ID: 6976062
• Report Number(s): BNL-44658; CONF-8910412--1; ON: DE90012119
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINES
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
AZAARENES
AZINES
AZOLES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BODY
BRAIN
CARBON 11
CARBON ISOTOPES
CARDIOTONICS
CARDIOVASCULAR AGENTS
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM AGENTS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
CHLORPROMAZINE
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DOPAMINE
DOSES
DRUGS
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
FLUORINE 18
FLUORINE ISOTOPES
HETEROCYCLIC COMPOUNDS
HOURS LIVING RADIOISOTOPES
HYDROXY COMPOUNDS
HYPNOTICS AND SEDATIVES
INDOLES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LABELLING
LIGANDS
LIGHT NUCLEI
MEMBRANE PROTEINS
MENTAL DISORDERS
MINUTES LIVING RADIOISOTOPES
NARCOTICS
NERVOUS SYSTEM
NEUROREGULATORS
NUCLEI
ODD-ODD NUCLEI
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PATIENTS
PHENOLS
PHENOTHIAZINES
POLYPHENOLS
POSITRON COMPUTED TOMOGRAPHY
PROTEINS
PS
PSYCHOLOGY
PSYCHOTROPIC DRUGS
PYRROLES
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RECEPTORS
SEROTONIN
SPIPERONE
SYMPATHOMIMETICS
TOMOGRAPHY
TRACER TECHNIQUES
TRANQUILIZERS
TRYPTAMINES