Assessing the activity of sarcoidosis: quantitative /sup 67/Ga-citrate imaging
Three different methods of quantitating /sup 67/Ga-citrate lung images - a visual index, a computer-assisted index, and the total-lung-to-background ratio - were compared in 71 studies of patients with biopsy-proven sarcoidosis. Fifty consecutive cases were analyzed independently by two different observers using all three methods. In these studies, each index was correlated with the cell differential in the bronchoalveolar lavage fluid. The total-lung-to-background ratio proved to be the simplest to perform; correlated best with the original visual index and the percentage of lymphocytes obtained in bronchoalveolar lavage fluid. Sensitivity for detecting active disease was 84% compared with 64% and 58% for the visual and computer-assisted indices, respectively, with no sacrifice in specificity.
- Research Organization:
- Emory Univ. Hospital, Atlanta, GA
- OSTI ID:
- 6974864
- Journal Information:
- Am. J. Roentgenol.; (United States), Vol. 142:4
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
GALLIUM 67
SCINTISCANNING
INFECTIOUS DISEASES
DIAGNOSIS
LUNGS
CITRATES
LAVAGE
PATIENTS
BETA DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACID SALTS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
GALLIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RESPIRATORY SYSTEM
550601* - Medicine- Unsealed Radionuclides in Diagnostics
550900 - Pathology