Induced renal artery stenosis in rabbits: magnetic resonance imaging, angiography, and radionuclide determination of blood volume and blood flow

Journal Article · Tue Mar 01 04:00:00 EST 1988 · Magn. Reson. Imag.; (United States)

DOI:https://doi.org/10.1016/0730-725X(88)90440-7· OSTI ID:6974145

Mitchell, D G; Tobin, M; LeVeen, R; Tomaczewski, J; Alavi, A; Staum, M; Kundel, H

To investigate the ability of MRI to detect alterations due to renal ischemia, a rabbit renal artery stenosis (RAS) model was developed. Seven rabbits had RAS induced by surgically encircling the artery with a polyethylene band which had a lumen of 1 mm, 1 to 2 weeks prior to imaging. The stenosis was confirmed by angiography, and the rabbits were then imaged in a 1.4 T research MRI unit. T1 was calculated using four inversion recovery sequences with different inversion times. Renal blood flow, using /sup 113/Sn-microspheres, and regional water content by drying were then measured. The average T1 of the inner medulla was shorter for the ischemia (1574 msec) than for the contralateral kidney (1849 msec), while no change ws noted in the cortex. Ischemic kidneys had less distinct outer medullary zones on IR images with TI = 600 msec than did contralateral or control kidneys. Blood flow to both the cortex and medulla were markedly reduced in ischemic kidneys compared with contralateral kidneys (119.5 vs. 391 ml/min/100 gm for cortex and 19.8 vs. 50.8 ml/min/100 gm for medulla). Renal water and blood content were less affected. Our rabbit model of renal artery stenosis with MRI, radionuclide, and angiographic correlation has the potential to increase our understanding of MR imaging of the rabbit kidney.

• Research Organization: Hospital of the Univ. of Pennsylvania, Philadelphia (USA)
• OSTI ID: 6974145
• Journal Information: Magn. Reson. Imag.; (United States), Journal Name: Magn. Reson. Imag.; (United States) Vol. 6:2; ISSN MRIMD
• Country of Publication: United States
• Language: English

Related Subjects

550600* -- Medicine
550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
550602 -- Medicine-- External Radiation in Diagnostics-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BIOLOGICAL MODELS
BIOMEDICAL RADIOGRAPHY
BLOOD
BLOOD CELLS
BLOOD FLOW
BODY
BODY FLUIDS
CARDIOVASCULAR DISEASES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
ERYTHROCYTES
EVEN-ODD NUCLEI
HYDROGEN COMPOUNDS
INTERMEDIATE MASS NUCLEI
ISCHEMIA
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
KIDNEYS
MAMMALS
MATERIALS
MEDICINE
MICROSPHERES
MINUTES LIVING RADIOISOTOPES
NMR IMAGING
NUCLEAR MEDICINE
NUCLEI
ORGANS
OXYGEN COMPOUNDS
RABBITS
RADIOISOTOPES
RADIOLOGY
TECHNETIUM ISOTOPES
TIN 113
TIN ISOTOPES
TRACER TECHNIQUES
VASCULAR DISEASES
VERTEBRATES
WATER