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Theoretical approach to the molecular conformation of nonfused biheterocycles. Bifurans and furylpyrroles

Journal Article · · J. Phys. Chem.; (United States)
DOI:https://doi.org/10.1021/j100287a011· OSTI ID:6970437

The internal torsional potential for the three structural isomers of bifuran (2,2'-, 2,3'-, and 3,3'-) and the four furylpyrroles (2,2'-, 2,3'-, 3,2'-, and 3,3'-) have been derived from standards SCF STO-3G and 4-31G calculations. Important differences in the potential shapes arise from the two basis sets mainly concerning the planar or out-of-planar structure of equilibrium conformations and the torsional barrier heights. The more relevant results are as follows: (i) 2,2'-isomers show twofold potentials and planar equilibrium conformations. The significance of the greater stability of the cis conformer of 2,2'-furylpyrrole is discussed. (ii) For the rest of the isomers, STO-3G predicts twofold potentials in all cases, whereas 4-31G potentials are found to be greatly dependent on the structure of the interannular region. In particular, fourfold potentials implying gauche out-of-plane equilibrium conformations and strong decreasing barrier heights are found whenever four hydrogen atoms are present in that region.

Research Organization:
Universidad de Valencia, Spain
OSTI ID:
6970437
Journal Information:
J. Phys. Chem.; (United States), Journal Name: J. Phys. Chem.; (United States) Vol. 91:3; ISSN JPCHA
Country of Publication:
United States
Language:
English