SPECT studies of brain tumors with L-3-( sup 123 I) iodo-alpha-methyl tyrosine: Comparison with PET, 124IMT and first clinical results
- Nuclear Research Center Juelich (Germany, F.R.)
L-3-({sup 123}I)iodo-alpha-methyltyrosine ({sup 123}IMT) like tyrosine has been reported previously to have a high affinity for a transport system in the blood-brain-barrier (BBB). We examined the kinetic behavior of {sup 124}IMT in brain and plasma in two patients with glioblastoma using dynamic positron emission tomography (PET). {sup 124}IMT accumulated in brain and tumor tissue, reaching a maximum after 15 min, with a washout of 20% to 35% at 60 min postinjection. Animal experiments confirmed the accumulation of the intact tracer in murine brain, but there was no incorporation into proteins. SPECT studies with {sup 123}IMT in patients with different types of brain tumors showed increased uptake in 26 of 32 tumors. Although nonspecific uptake in tumors must be considered, the accumulation of IMT in normal brain and in some tumors with intact BBB suggests a specific uptake of IMT. As transport is the main determinant of initial amino acid uptake, {sup 123}IMT appears to be a suitable SPECT tracer of amino acid uptake although it is not incorporated into protein.
- OSTI ID:
- 6969332
- Journal Information:
- Journal of Nuclear Medicine; (USA), Journal Name: Journal of Nuclear Medicine; (USA) Vol. 31:3; ISSN 0161-5505; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINO ACIDS
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL ACCUMULATION
BLOOD-BRAIN BARRIER
BODY
BRAIN
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM
COMPARATIVE EVALUATIONS
COMPUTERIZED TOMOGRAPHY
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
GLIOMAS
HOURS LIVING RADIOISOTOPES
HYDROXY ACIDS
IMAGE PROCESSING
INTERMEDIATE MASS NUCLEI
IODINE 123
IODINE ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MICE
NEOPLASMS
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PATIENTS
POSITRON COMPUTED TOMOGRAPHY
PROCESSING
RADIOISOTOPES
RADIOPHARMACEUTICALS
RODENTS
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
TOMOGRAPHY
TYROSINE
VERTEBRATES